Description:
7-Keto (3-Acetyl-7-Oxo-dehydroepiandrosterone) is a naturally occurring metabolite of DHEA (dehydroepiandrosterone). In the body, 7-Keto is not converted into testosterone or estrogen to any appreciable degree. 7-Keto, as a downstream metabolite of DHEA, is produced in the body during the degradation of DHEA. 7 Keto can be measured in the blood as a ketosteroid.
Claims:Improves immune system function Aids in weight reduction / Thermogenic Supports thyroid function Non-androgenic or estrogenic Enhances memory
Theory:
Because 7-Keto is a downstream metabolite of DHEA it is promoted as being a “non-androgenic” or “estrogenic” version of DHEA. It is also promoted as a weight loss aid for its supposed thermogenic effect. Animal studies demonstrate that it can enhance thermogenesis, which may translate into weight loss. Because DHEA levels decline as we age and ketosteroids are made from DHEA, all conditions which may benefit from DHEA supplementation, may also benefit from 7-Keto.
Scientific Support:
7-Keto supplements, at a dose of 200mg/day in adults ~25 to 55 years of age has been shown in one poorly designed trial to enhance weight loss, aid in the reduction of body fat and effect thyroid hormone levels. This two-month study also demonstrated that 7-Keto does not significantly effect blood sugar, testosterone, estradiol, liver or kidney function, but the “significant” weight loss benefits were more do to an unbalanced study designthan to any real benefit of the supplement (the group receiving the supplement were significantly heavier/fatter at the start of the study compared to the control group). Another study showed that 200mg/day of 7-Keto for 8 weeks does not effect dihydrotestosterone (DHT), estradiol, cortisol and insulin levels in men 18-49 years of age. Several animal studies have demonstrated that 7-Keto, like other anabolic hormones, can induce thermogenic enzymes. One trial with 7-Keto demonstrated that it could bolster interleukin 2 production in lymphocytes, but this study was conducted in cells (in vitro) and not in humans. 7-Keto has also been shown in mice to improve memory (water maze procedure).
Safety:
7-Keto appears to be safe in doses of 200mg per day. The two human trials to date have not shown any androgenic or estrogenic effects of high dose supplementation. Many of the claims for 7-Keto are based on petri dish studies, animal research and cell line studies, thus the data and findings cannot be carried over to the human model.
Value:
The scientific evidence for using 7-Keto as either an anabolic agent or for promoting weight loss is quite weak and more research is needed to substantiate if any of the popular claims made for this supplement are indeed justified.
Dosage:
The few human trials have used a 200mg/day dose – but commercial supplements typically provide about 50mg/day.
7-Keto DHEA Vs DHEA
If you've been doing research on DHEA, you've probably also heard of 7-Keto DHEA. But what is the difference and which one is the right one for you?
7-Keto DHEA is a biologically active metabolite of DHEA that promotes better health and energy without the potential side effects of increased amounts of hormones. 7-Keto DHEA boosts the immune system by increasing the production of certain types of white blood cells; it increases energy and metabolism by activating enzymes in the liver that boost the rate of thermogensis (the process by which fat is burned).
7-Keto has all the non-hormonal effects of DHEA, and may even be more potent in this regard. However 7-Keto will not have some of the effects that DHEA has such as improved libido.
DHEA is the most plentiful hormone in the human body, but its production declines with age. As the levels of DHEA decrease, so does this important metabolite, 7-KETO. The levels of DHEA and its numerous derivatives, manufactured in the adrenal glands, begin to decline after the age of 30 with about a 50% decline by the age of 40 and about 85% decline by the age of 70. As these hormone levels decline during the aging process, there are some detrimental physiological and anatomical effects which occur as a result. These include a reduction in protein biosynthesis which lead to a loss in muscle mass, and reduction in bone tissue regeneration which causes a loss of bone mass (a risk factor for osteoporosis). Other effects include the decline in the metabolic rate which causes an increase in fat accumulation, a decline in various immune system functions, and an increased rate of memory loss.
One of the effects n of 7-KETO in a double blind, placebo controlled human, clinical trial was the stimulation of liver enzymes, which increase heat production using fat as the primary source of energy. Naturally, this resulted in the reduction of adipose fat tissue when combined with exercise. Other clinical studies in humans indicated 7-KETO improved immunity and also memory-related functions. In all cases, 7-KETO was demonstrated to be substantially more effective than DHEA without the sex hormone related, side effects.
The safety evaluation of 7-KETO has been done through observations from an extensive number of pre-clinical and clinical safety studies in both humans and animal subjects. In all cases, 7-KETO was consistently found to be safe for human consumption as a dietary supplement.
7-keto 7 metabolic pathways
ลดไขมันด้วยกลไกการเผาผลาญอย่างธรรมชาติ 7วิธี
1.เร่งอัตราการเผาผลาญในร่างกายอย่างธรรมชาติ
2.ป้องกันการทําลายกล้ามเนื้อ ทําให้เมื่อลดน้ำหนักแล้ว ไม่โทรม กล้ามเนื้อคมกระชับไม่เหลว
3.นําไขมันเก่าที่สะสมในบริเวณต่างๆออกมาใช้เป็นพลังงานหลัก
4.ป้องกันไม่ให้ร่างกายเก็บสะสมไขมันใหม่
5.ข้อนี้เด็ดสุดช่วยในการเผาผลาญแป้ง สําหรับคนที่ทานแป้งแล้วอ้วนง่าย
6.ช่วยลดอาการหน้าบวม ทําให้รูปหน้าดูเรียวเป็นรูปไข่
7.ลดปริมาณไขมันอุตตันในเส้นเลือด
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